Locked warp paths throughout the galaxy:
Rigel - Rainsford, Rainsford - Lydan, Rainsford - Raddan, Lydan - Tera Lara, and Raddan - Tera Lara: unlocked by completing the mission "Retrofit". This mission belongs to a chain that starts with the mission "Uncaged". To get the first mission and begin the chain you can visit one of the following systems: Elona, Zaurak, Azha, Amador, Midnight, Obilent, Lycia, Labac, or Astrida.
Tera Lara - Rona Tan, Rona Tan - Gealan, Rona Tan - Kor Na Ron, Kor Na Ron - Terazon X31, and Kor Na Ron - Paradane: unlocked by completing the mission "Volatile Combinations". This mission belongs to a chain that starts with the mission "Uncaged". To get the first mission and begin the chain you can visit one of the following systems: Elona, Zaurak, Azha, Amador, Midnight, Obilent, Lycia, Labac, or Astrida.
Kor Na Ron - Duriana, Duriana - Vellamo, Duriana - Ifrea 3, and Ifrea 3 - Olassa: unlocked by completing the mission "Recuperation". This mission belongs to a chain that starts with the mission "Uncaged". To get the first mission and begin the chain you can visit one of the following systems: Elona, Zaurak, Azha, Amador, Midnight, Obilent, Lycia, Labac, or Astrida.
Ifrea 3 - Orda 877, Orda 877 - Ilmatar, and Ilmatar - Yarda 74: unlocked by completing the "Receding Light" mission. This mission belongs to a chain that starts with the mission "Uncaged". To get the first mission and begin the chain, you can visit one of the following systems: Elona, Zaurak, Azha, Amador, Midnight, Obilent, Lycia, Labac, or Astrida.
Duriana - Yarda 74 and Quvolis - Yarda 74: unlocked by completing the "Autopilot: Yarda" mission, which can be picked up in Yarda.
Rona Tan - Duriana: unlocked by completing the mission "Autopilot: Duriana" which can be picked up in Duriana.
Eojur - Tera Lara: unlocked by completing the mission "Autopilot: Tera Lara" which can be picked up in Tera Lara.
Earorfilad - Mordus and Tejat - Torana: these long-deserted paths have been shrouded with mystery for the past eons. We've sent out multiple probes to gather intel, but still, we haven't been able to piece the puzzle together.
Ty'Gokor - Ester and Brestant - Orasi 18: unlocked by researching the node named "Origin & Borg Superhighways" located in the Combat Research tree.
Talmir 86 - Ambit: unlocked by completing the mission "Now and Then Part 9". This mission belongs to a chain that starts with the mission "Now and Then Part 1". To get the first mission and begin the chain, you need to purchase it through the TOS tab in the Holodeck.
Haakona - Garadius, Bolarus - Fibona, and Balduk - Ty'Rall: unlocked by completing the mission "Dark Space" and has a required Ops level 39. This mission belongs to the main mission chain*.
Rek'Sgar - Beta Sector and Welma - Beta Sector: unlocked by completing the mission "The Price We Pay" and has a required Ops level 39. This mission belongs to the main mission chain*.
Umxheli - New Vulcan and Ash-tor - New Vulcan: unlocked by completing the mission "Twists and Turns" and has a required Ops level 40. This mission belongs to the main mission chain*.
Nikola - Singularity Apex: unlocked by completing the mission "Forwards is Backwards" and has a required Ops level 40. This mission belongs to the main mission chain*.
Hauge-Kalalisko: unlocked by completing the mission "Take Arms against an Empire of Troubles III" and has a required Ops level 51. This mission belongs to the main mission chain*.
System J-25 - Jiiny; Jiiny - Malon Vortex and Malon Vortex - Velixys: unlocked by completing the mission "Voyage to Velixys”. The mission will be available in the Voyager Refinery after the "Delta Quadrant Analysis" research has been completed (Starships Research Tree).
Velixys - Asil-A: unlocked by completing the mission "Voyage to Asia-A”. The mission will be available in the Voyager Refinery after the "Delta Quadrant Analysis" research has been completed (Starships Research Tree).
Asil-A to Bartu'shakai: unlocked by completing the mission "Voyage to Bartu'shakaiI”. The mission will be available in the Voyager Refinery after the "Delta Quadrant Analysis" research has been completed (Starships Research Tree).
Bartu'shakai to Illysus: unlocked by completing the mission "Voyage to Illusys”. The mission will be available in the Voyager Refinery after the "Delta Quadrant Analysis" research has been completed (Starships Research Tree).
*To learn more about this, please review the guide >>Main Missions<<.